Modern Pharmacology With Clinical Applications, Medycyna all, Farmakologia
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PREFACE
Clinical Applications
continues our commitment
to enlisting experts in pharmacology to provide
a textbook that is up-to-date and comprehensive. De-
signed to be used during a single semester, the book fo-
cuses on the clinical application of drugs within a con-
text of the major principles of pharmacology. It is meant
to serve students in medicine, osteopathy, dentistry,
pharmacy, and advanced nursing, as well as undergrad-
uate students.
clinical scenarios and require them to apply their
knowledge to solve the problem.
Refined Focus:
In this edition, we chose to focus
more on drug classes rather than on individual drugs,
eliminate unnecessary detail such as chemical struc-
tures, and maintain emphasis on structure–activity rela-
tionships in drug action and development.
Updated Information:
This edition also includes
new information from the clinic and the laboratory.
Emerging information has been added within chapters
and when appropriate (as in the case of herbal drugs
and erectile dysfunction), through the addition of new
chapters.
With these revisions, we hope we have provided a
book that is readable, up-to-date, comprehensive but
not exhaustive, and accurate—a text that supplies both
students and faculty with a clear introduction to mod-
ern pharmacotherapeutics.
SUMMARY OF FEATURES
This edition includes a number of new or updated fea-
tures that further enhance the appeal of the text.
Study Questions:
Each chapter includes five to
seven examination questions (following the United
States Medical Licensing Examination guidelines) with
detailed answers to help students test their knowledge
of the covered material.
Case Studies:
Appearing at the end of each chapter,
case studies present students with real-life examples of
Charles R. Craig
Robert E. Stitzel
T
he sixth edition of
Modern Pharmacology With
TABLE OF CONTENTS
I.
GENERAL PRINCIPLES OF PHARMACOLOGY
19. Calcium Channel Blockers
218
1. Progress in Therapeutics 03
Robert E. Stitzel and Joseph J. McPhillips
2. Mechanisms of Drug Action
Vijay C. Swamy and David J. Triggle
20. Antihypertensive Drugs
225
10
David P. Westfall
21. Diuretic Drugs 239
Peter A. Friedman and William O. Berndt
22. Anticoagulant, Antiplatelet, and Fibrinolytic
(Thrombolytic) Drugs
William W. Fleming
3. Drug Absorption and Distribution
20
Timothy S. Tracy
4. Metabolism and Excretion of Drugs
34
256
Jeffrey S. Fedan
23. Hypocholesterolemic Drugs and Coronary Heart
Disease 268
Richard J. Cenedella
Timothy S. Tracy
5. Pharmacokinetics
48
Timothy S. Tracy
6. Drug Metabolism and Disposition in Pediatric and
Gerontological Stages of Life
56
IV.
DRUGS AFFECTING THE CENTRAL NERVOUS
SYSTEM
Jeane McCarthy
7. Principles of Toxicology
63
Mary E. Davis and Mark J. Reasor
8. Contemporary Bioethical Issues in Pharmacology and
Pharmaceutical Research
24. Introduction to Central Nervous System
Pharmacology
281
73
Charles R. Craig
25. General Anesthesia: Intravenous and Inhalational
Agents 291
David J. Smith and Michael B. Howie
26. Opioid and Nonopioid Analgesics
Janet Fleetwood
II.
DRUGS AFFECTING THE AUTONOMIC NERVOUS
SYSTEM
310
9. General Organization and Functions of the Nervous
System 83
William W. Fleming
10. Adrenomimetic Drugs 96
Tony J.-F. Lee and Robert E. Stitzel
11. Adrenoceptor Antagonists
Sandra P. Welch and Billy R. Martin
27. Local Anesthetics
336
J. David Haddox
28. Agents Affecting Neuromuscular
Transmission
338
109
Michael D. Miyamoto
29. Central Nervous System Stimulants
348
David P. Westfall
12. Directly and Indirectly Acting
Cholinomimetics
121
David A. Taylor
30. Sedative–Hypnotic and Anxiolytic Drugs
355
John W. Dailey
31. Drugs Used in Neurodegenerative Disorders
William F. Wonderlin
13. Muscarinic Blocking Drugs
134
364
Patricia K. Sonsalla
32. Antiepileptic Drugs
William F. Wonderlin
14. Ganglionic Blocking Drugs and Nicotine
141
374
Charles R. Craig
33. Drugs Used in Mood Disorders
Thomas C. Westfall
385
III.
Drugs Affecting the Cardiovascular System
Herbert E. Ward and Albert J. Azzaro
34. Antipsychotic Drugs
397
15. Pharmacologic Management of Chronic Heart
Failure 151
Mitchell S. Finkel and Humayun Mirza
16. Antiarrhythmic Drugs 160
Peter S. Fischbach and Benedict R. Lucchesi
17. Antianginal Drugs
Stephen M. Lasley
35. Contemporary Drug Abuse
406
Billy R. Martin and William L. Dewey
196
V.
THERAPEUTIC ASPECTS OF INFLAMMATORY
AND SELECTED OTHER CLINICAL DISORDERS
Garrett J. Gross
18. The Renin–Angiotensin–Aldosterone System and Other
Vasoactive Substances
36. Antiinflammatory and Antirheumatic Drugs
423
206
Karen A. Woodfork and Knox Van Dyke
37. Drugs Used in Gout
441
Lisa A. Cassis
Knox Van Dyke
xi
xii
TABLE OF CONTENTS
38. Histamine and Histamine Antagonists
449
55. The Rational Basis for Cancer
Chemotherapy
Knox Van Dyke and Karen A. Woodfork
39. Drugs Used in Asthma 458
Theodore J. Torphy and Douglas W. P. Hay
40. Drugs Used in Gastrointestinal Disorders
630
Branimir I. Sikic
56. Antineoplastic Agents
638
470
Branimir I. Sikic
57. Immunomodulating Drugs
Lisa M. Gangarosa and Donald G. Seibert
41. Drugs Used in Dermatological Disorders 484
Eric L. Carter, Mary-Margaret Chren, and David R. Bickers
42. Drugs for the Control of Supragingival
Plaque 499
Angelo Mariotti and Arthur F. Hefti
657
Leonard J. Sauers
58. Gene Therapy 666
John S. Lazo and Jennifer Rubin Grandis
VII.
DRUGS AFFECTING THE ENDOCRINE SYSTEM
VI.
CHEMOTHERAPY
59. Hypothalamic and Pituitary Gland
Hormones 677
Priscilla S. Dannies
60. Adrenocortical Hormones and Drugs Affecting the
Adrenal Cortex
43. Introduction to Chemotherapy
509
Steven M. Belknap
44. Synthetic Organic Antimicrobials: Sulfonamides,
Trimethoprim, Nitrofurans, Quinolones,
Methenamine 515
Marcia A. Miller-Hjelle, Vijaya Somaraju, and J. Thomas Hjelle
45. -Lactam Antibiotics
686
Ronald P. Rubin
61. Estrogens, Progestins, and SERMs
704
526
Jeannine S. Strobl
62. Uterine Stimulants and Relaxants
716
James F. Graumlich
46. Aminoglycoside Antibiotics
538
Leo R. Brancazio and Robert E. Stitzel
63. Androgens, Antiandrogens, and Anabolic
Steroids 724
Frank L. Schwartz and Roman J. Miller
64. Drugs Used in the Treatment of Erectile
Dysfunction 735
John A. Thomas and Michael J. Thomas
65. Thyroid and Antithyroid Drugs
Steven Belknap
47. Tetracyclines, Chloramphenicol, Macrolides, and
Lincosamides
544
Richard P. O’Connor
48. Bacitracin, Glycopeptide Antibiotics, and the
Polymyxins
552
742
Mir Abid Husain
49. Drugs Used in Tuberculosis and Leprosy
557
John Connors
66. Parathyroid Hormone, Calcitonin, Vitamin D, and Other
Compounds Related to Mineral Metabolism
Vijaya Somaraju
50. Antiviral Drugs 567
Knox Van Dyke and Karen Woodfork
51. Therapy of Human Immunodeficiency Virus
754
Frank L. Schwartz
67. Insulin and Oral Drugs for Diabetes Mellitus
763
584
Michael J. Thomas and John A. Thomas
68. Vitamins
Knox Van Dyke and Karen Woodfork
52. Antifungal Drugs
777
596
Suzanne Barone
69. Herbal Medicine
David C. Slagle
53. Antiprotozoal Drugs
785
606
Gregory Juckett
Index
Leonard William Scheibel
54. Anthelmintic Drugs 621
Mir Abid Husain and Leonard William Scheibel
I
GENERAL PRINCIPLES
OF PHARMACOLOGY
SECTION
I
1. Progress in Therapeutics
3
Robert E. Stitzel and Joseph J. McPhillips
2. Mechanisms of Drug Action
10
6. Drug Metabolism and Disposition in
Pediatric and Gerontological Stages
of Life
••
Jeane McCarthy
7. Principles of Toxicology
••
Mary E. Davis and Mark J. Reasor
8. Contemporary Bioethical Issues in
Pharmacology & Pharmaceutical
Research
••
Janet Fleetwood
William W. Fleming
3. Drug Absorption and Distribution
20
Timothy S. Tracy
4. Metabolism and Excretion of Drugs
••
Timothy S. Tracy
5. Pharmacokinetics
••
Timothy S. Tracy
1
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